Dr. Bush is a thoracic surgeon and surgical director of the Advanced Lung Disease and Lung Transplant Program for the Johns Hopkins Comprehensive Transplant Center. He also serves as director of the Ex vivo Lung Perfusion Program.

Dr. Bush specializes in the surgical treatment of chronic and end-stage lung diseases, as well as benign (non-cancerous) and malignant (cancerous) diseases and lesions of the chest. He is skilled in minimally invasive operations such as video-assisted thoracoscopic surgery, a type of thoracic surgery performed using a small video camera that is introduced into the patient's chest via a scope to treat lung and esophageal cancers. Dr. Bush also has experience with extracorporeal membrane oxygenation (ECMO), a technique of providing both cardiac and respiratory support oxygen to patients whose heart and lungs can no longer serve their function.

His research interests include investigations of outcomes and health disparities related to lung cancer, lung transplant, and ECMO patients. Dr. Bush is currently leading several open clinical trials.